Spray Congealing: An Emerging Technology to Prepare Solid Dispersions with Enhanced Oral Bioavailability of Poorly Water Soluble Drugs

Solid Dispersions: An Overview To Modify Bioavailability Of Poorly Water Soluble Drugs

Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs.

Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability, bioavailability may be significantly improved. They are usually presented as amorphous products, mainly obtained by two major different methods, for example, melting and solvent...

Nanocrystal Technology For Oral Delivery of Poorly Water-Soluble Drugs

Nanotechnology has been improving and has a variety of application fields. One of the major application areas of nanotechnology in pharmacy is nanoparticular drug delivery systems. Preparation of drug nanocrystals to improve the solubility of poorly water-soluble drugs for oral delivery is also one of the important applications. Nanocrystal dispersions comprise water, active drug substance and ...

Pharmaceutical Technologies for Enhancing Oral Bioavailability of Poorly Soluble Drugs

The oral bioavailability of BCS (biopharmaceutics classification system) class II drugs with poor solubility and reasonable permeability is limited by the drug dissolution step from drug products. Though prodrug approach is an exciting way of improving the oral bioavailability, it requires extensive studies to establish the safety profile of prodrugs in humans. In view of the increasing market ...

Functions of Lipids for Enhancement of Oral Bioavailability of Poorly Water-Soluble Drugs

Lipid-based formulations encompass a diverse group of formulations with very different physical appearance, ranging from simple triglyceride vehicles to more sophisticated formulations such as self-emulsifying drug delivery systems (SEDDS). Lipid-based drug delivery systems may contain a broad range of oils, surfactants, and co-solvents. They represent one of the most popular approaches to over...